Sunday, March 31, 2013

The South: A near-solid block against 'Obamacare'

FILE ? In this March 15, 2013 file photo Republican governor of South Carolina Nikki Haley speaks at the 40th annual Conservative Political Action Conference (CPAC) in National Harbor, Md. As more Republicans give in to President Barack Obama?s health-care overhaul, an opposition bloc remains across the South, which includes governors who lead some of the nation?s poorest and unhealthiest states. ?We will not expand Medicaid on President Obama?s watch. We will not expand Medicaid ever,? Haley told the audience at CPAC. Medicaid is financed mostly by Congress, with state?s putting up match funding. Obama?s law mandated that states open Medicaid to everyone with household income up to 133 percent of the federal poverty rate, but the Supreme Court ruled states must have a choice. (AP Photo/Manuel Balce Ceneta, File)

FILE ? In this March 15, 2013 file photo Republican governor of South Carolina Nikki Haley speaks at the 40th annual Conservative Political Action Conference (CPAC) in National Harbor, Md. As more Republicans give in to President Barack Obama?s health-care overhaul, an opposition bloc remains across the South, which includes governors who lead some of the nation?s poorest and unhealthiest states. ?We will not expand Medicaid on President Obama?s watch. We will not expand Medicaid ever,? Haley told the audience at CPAC. Medicaid is financed mostly by Congress, with state?s putting up match funding. Obama?s law mandated that states open Medicaid to everyone with household income up to 133 percent of the federal poverty rate, but the Supreme Court ruled states must have a choice. (AP Photo/Manuel Balce Ceneta, File)

Georgia Gov. Nathan Deal addresses the Senate on the last day of the legislative session, Thursday, March 28, 2013, in Atlanta. Deal paid legislators a visit late Thursday afternoon as lawmakers neared the final gavel of the 2013 session. It's a ceremonial tradition for Deal, who served in the General Assembly before being elected to Congress and then the governor's office. But the governor is able to celebrate a session that gave him most of what he wanted from lawmakers. (AP Photo/David Goldman)

(AP) ? As more Republicans give in to President Barack Obama's health-care overhaul, an opposition bloc remains across the South, including from governors who lead some of the nation's poorest and unhealthiest states.

"Not in South Carolina," Gov. Nikki Haley declared at the recent Conservative Political Action Conference. "We will not expand Medicaid on President Obama's watch. We will not expand Medicaid ever."

Widening Medicaid insurance rolls, a joint federal-state program for low-income Americans, is an anchor of the law Obama signed in 2010. But states get to decide whether to take the deal, and from Virginia to Texas ? a region encompassing the old Confederacy and Civil War border states ? Florida's Rick Scott is the only Republican governor to endorse expansion, and he faces opposition from his GOP colleagues in the legislature. Tennessee's Bill Haslam, the Deep South's last governor to take a side, added his name to the opposition on Wednesday.

Haley offers the common explanation, saying expansion will "bust our budgets." But the policy reality is more complicated. The hospital industry and other advocacy groups continue to tell GOP governors that expansion would be a good arrangement, and there are signs that some Republicans are trying to find ways to expand insurance coverage under the law.

Haslam told Tennessee lawmakers that he'd rather use any new money to subsidize private insurance. That's actually the approach of another anchor of Obama's law: insurance exchanges where Americans can buy private policies with premium subsidies from taxpayers.

Yet for now, governors' rejection of Medicaid expansion will leave large swaths of Americans without coverage because they make too much money to qualify for Medicaid as it exists but not enough to get the subsidies to buy insurance in the exchanges. Many public health studies show that the same population suffers from higher-than-average rates of obesity, smoking and diabetes ? variables that yield bad health outcomes and expensive hospital care.

"Many of the citizens who would benefit the most from this live in the reddest of states with the most intense opposition," said Drew Altman, president of the non-partisan Kaiser Family Foundation.

So why are these states holding out? The short-term calculus seems heavily influenced by politics.

Haley, Haslam, Nathan Deal of Georgia and Robert Bentley of Alabama face re-election next year. Mississippi Gov. Phil Bryant is up for re-election in 2015. Louisiana Gov. Bobby Jindal is term-limited at home but may seek the presidency in 2016. While they all govern GOP-leaning states, they still must safeguard their support among Republican voters who dislike large-scale federal initiatives in general and distrust Obama in particular. Florida's Scott, the South's GOP exception on expansion, faces a different dynamic. He won just 49 percent of the vote in 2010 and must face an electorate that twice supported Obama.

A South Carolina legislator put it bluntly earlier this year. State Rep. Kris Crawford told a business journal that he supports expansion, but said electoral math is the trump card. "It is good politics to oppose the black guy in the White House right now, especially for the Republican Party," he said.

Whit Ayers, a leading Republican pollster, was more measured, but offered the same bottom line. "This law remains toxic among Republican primary voters," he told The Associated Press.

At the Tennessee Hospital Association, president Craig Becker has spent months trying to break through that barrier as he travels to civic and business groups across Tennessee. "It's really hard for some of them to separate something that has the name 'Obamacare' on it from what's going to be best for the state," he said, explaining that personality driven politics are easier to understand than the complicated way that the U.S. pays for health care.

Medicaid is financed mostly by Congress, though states have to put in their own money to qualify for the cash from Washington. The federal amount is determined by a state's per-capita income, with poorer states getting more help. On average in 2012, the feds paid 57 cents of every Medicaid dollar. It was 74 cents in Mississippi, 71 in Kentucky, 70 in Arkansas and South Carolina, 68 in Alabama. Those numbers would be even higher counting bonuses from Obama's 2009 stimulus bill.

Obama's law mandated that states open Medicaid to everyone with household income up to 138 percent of the federal poverty rate ? $15,420 a year for an individual or $31,812 for a family of four. The federal government would cover all costs of new Medicaid patients from 2014 to 2016 and pick up most of the price tag after that, requiring states to pay up to 10 percent. The existing Medicaid population would continue under the old formula. In its ruling on the law, the Supreme Court left the details alone, but declared that states could choose whether to expand.

Hospital and physician lobbying groups around the country have endorsed a bigger Medicaid program. Becker said he explains on his road show that the Obama law paired Medicaid growth with cuts to payments to hospitals for treating the uninsured. Just as they do with Medicaid insurance, states already must contribute their own money in order to get federal help with those so-called "uncompensated care" payments.

The idea was instead of paying hospitals directly, states and Congress could spend that money on Medicaid and have those new beneficiaries ? who now drive costs with preventable hospital admissions and expensive emergency room visits ? use the primary care system. But the Supreme Court ruling creates a scenario where hospitals can lose existing revenue with getting the replacement cash Congress intended, all while still having to treat the uninsured patients who can't get coverage.

Becker said that explanation has gotten local chambers of commerce across Tennessee to endorse expansion. "These are rock-ribbed Republicans," he said. "But they all scratch their heads and say, 'Well, if that's the case, then of course we do this.'"

In Louisiana, Jindal's health care agency quietly released an analysis saying the changes could actually save money over time. But the Republican Governors Association chairman is steadfast in his opposition. In Georgia, Deal answers pressure from his state's hospital association with skepticism about projected "uncompensated care" savings and Congress' pledge to finance 90 percent of the new Medicaid costs.

Altman, the Kaiser foundation leader, predicted that opposition will wane over time.

Arkansas Republicans, who oppose Democratic Gov. Mike Beebe's call for expansion, have floated the same idea as Haslam: pushing would-be Medicaid recipients into the insurance exchanges. Jindal, using his RGA post, has pushed the Obama administration to give states more "flexibility" in how to run Medicaid.

Deal convinced Georgia lawmakers this year to let an appointed state board set a hospital industry tax to generate some of the state money that supports Medicaid. That fee ? which 49 states use in some way ? is the same tool that Arizona Gov. Jan Brewer is using to cover her state's Medicaid expansion. Georgia Democrats and some hospital executives have quietly mused that Deal is leaving himself an option to widen Medicaid in his expected term.

"These guys are looking for ways to do this while still saying they are against 'Obamacare,'" Altman said. "As time goes by, we'll see this law acquire a more bipartisan complexion."

-----

Follow Barrow on Twitter (at)BillBarrowAP.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-03-30-US-Medicaid-South/id-d25f617a548b4650a44ae4581e58805c

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Report: Facebook's Secret Android Project Isn't a Facebook Phone But a Home Screen Dedicated to Facebook

The WSJ is reporting that Facebook's upcoming Android event will be a home screen—as in the first screen you see when you flip on your phone—dedicated to Facebook. It will "display content from users' Facebook accounts on a smartphone's home screen." More »


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Ben Carson, the neurosurgeon-turned-conservative-pundit, has accumulated legions of right-leaning fans since he stumped at the National Prayer Breakfast in February and, later, began appearing on Fox News Channel. But after delivering widely condemned comments regarding gay people?on Fox this week, a group of students at Johns Hopkins, where Carson has worked since 1977, has successfully stopped Carson from speaking?at the May commencement ceremony?of the university's medical school. ...

Source: http://news.yahoo.com/99-ouya-game-console-set-june-4th-release-205942141.html

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Obama takes jobs pitch to Miami

President Barack Obama will promote a plan to create jobs by attracting private investment in highways and other public works during a visit Friday to a Miami port, the White House said.

The president will flesh out details of his proposals in a speech at the port, which is undergoing $2 billion in upgrades paid for with government and private money. Obama, in the quick trip to South Florida, will try to show that the economy remains his top priority in the midst of high-profile campaigns on immigration reform and gun control.

Among the proposals Obama will call for:

?Higher caps on "private activity bonds" to encourage more private spending on highways and other infrastructure projects. State and local governments use the bonds to attract investment.

?Giving foreign pension funds tax-exempt status when selling U.S. infrastructure, property or real estate assets. U.S. pension funds are generally tax exempt in those circumstances. The administration says some international pension funds cite the tax burden as a reason for not investing in American infrastructure.

?$4 billion in new spending on two infrastructure programs that award loans and grants.

?A renewed call for a $10 billion national "infrastructure bank" ? a proposal from his first term that gained little traction.

The president made private-sector infrastructure investment a key part of the economic agenda he rolled out in his State of the Union address last month. He also called in his address for a "Fix-It-First" program that would spend $40 billion in taxpayer funds on urgent repairs.

Obama's focus on generating more private sector investment underscores the tough road new spending faces on Capitol Hill, where Republican lawmakers often threaten to block additional spending unless it is paid for by tax cuts or other measures.

Any increased spending associated with the proposals Obama was outlining Friday would not add to the deficit, a senior administration official said. The official was not authorized to discuss the plan in advance of Obama's announcement and spoke on condition of anonymity.

The official did not detail how the costs would be paid for, saying only that more information would be included in the president's budget.

Obama will release his budget April 10.

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Follow Josh Lederman on Twitter: http://twitter.com/joshledermanAP

Follow Julie Pace on Twitter: http://twitter.com/jpaceDC

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Source: http://news.yahoo.com/obama-pitch-more-jobs-public-142807078.html

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Lindsay Lohan Steals from Anger Managament Set

Source: http://www.thehollywoodgossip.com/2013/03/lindsay-lohan-steals-from-anger-managament-set/

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Mauritius unemployment rises to 8.1 percent in 2012

By Jean Paul Arouff

PORT LOUIS (Reuters) - The unemployment rate in Mauritius rose to 8.1 percent in 2012 from 7.9 percent a year earlier, data showed on Friday, pushed up by a weak global economy that hurt the island's tourism sector and exports.

Statistics Mauritius said that, in the fourth quarter, the jobless rate rose by 0.3 percentage points to 7.8 percent.

The island state's international trade, which includes textile products, is heavily skewed towards the economically troubled euro zone, accounting for 67 percent of exports. The region is also the biggest source of tourists.

The statistics agency this week said it had cut its growth forecast for this year to 3.5 percent from 3.7 percent, citing a deeper contraction in the construction industry.

The Bank of Mauritius left its benchmark lending rate unchanged at 4.9 percent this month.

Source: http://news.yahoo.com/mauritius-unemployment-rises-8-1-percent-2012-124142324--finance.html

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Sony's Light Shaft, Motion Shot apps now available for NEX-5R and NEX-6 cams

Sony's Light Shaft, Motion Shot apps now available for NEX5R and NEX6 cams

One could easily argue that apps are a dime a dozen nowadays, but for those with a WiFi-ready, mirrorless Sony shooter, the in-cam software selection is still somewhat limited. As of a few hours ago, though, NEX-5R and NEX-6 owners now have two more options to choose from, thanks to Sony's new Light Shaft and Motion Shot applications. For starters, Light Shaft, as the company describes it, brings "a splash of light" to any picture using numerous differently shaped effects, such as Beam, Flare, Ray and Star. Motion Shot, on the other hand, takes multiple, continuous shots that are then superimposed to add a little flavor to action snaps, allowing users to easily pick the first and last images of every sequence. Available now via the PlayMemories shop, both apps are priced at $4.99 each -- which, to some, might feel like too steep a price to pay for a little unorthodox editing. We'll leave that decision up to you, though.

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Via: DPReview

Source: Sony

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Saturday, March 30, 2013

Protective prion keeps yeast cells from going it alone

Friday, March 29, 2013

Most commonly associated with such maladies as "mad cow disease" and Creutzfeldt-Jakob disease, prions are increasingly recognized for their ability to induce potentially beneficial traits in a variety of organisms, yeast chief among them.

Now a team of scientists has added markedly to the job description of prions as agents of change, identifying a prion capable of triggering a transition in yeast from its conventional single-celled form to a cooperative, multicellular structure. This change, which appears to improve yeast's chances for survival in the face of hostile environmental conditions, is an epigenetic phenomenon?a heritable alteration brought about without any change to the organism's underlying genome.

This latest finding, reported in the March 28 issue of the journal Cell, has its origins in work begun several years ago in the lab of Whitehead Institute Member Susan Lindquist. In 2009, Randal Halfmann, then a graduate student in Lindquist's lab, identified dozens of proteins in yeast that have the ability to form prions. That research greatly expanded the known universe of prion elements in yeast, but it failed to answer a key question: What function, if any, do these prions actually have?

In search of an answer, Halfmann, now a fellow the University of Texas Southwestern Medical Center, and colleagues in the Lindquist lab attempted to exploit the fact that several of the prion-forming proteins they had identified acted to modify transcription of yeast genes. It stood to reason that if they could identify which genes were being regulated, they might be able to determine the prions' function.

"We looked at the five transcriptional regulators that are known to be prions in yeast, and we found that in fact, only one gene in the entire yeast genome was regulated by all five transcription factors," says Halfmann.

That gene, as it turns out, was FLO11, a key player in multicellularity in yeast. Indeed changes in FLO11 expression have been shown to act as a toggle, switching yeast from spherical to filamentous form. Halfmann notes that FLO11, which has been shown to be regulated by epigenetic elements, is also highly responsive to environmental stress. Knowing that the prion form of a protein is essentially a misfolded form of that protein, and that stressful conditions increase the frequency of protein misfolding and prion formation, the scientists began to consider the possibility that the prions themselves might be among the epigenetic switches influencing the activity of FLO11.

The group focused on one transcription factor known as mot3, finding that yeast cells containing the prion form of this factor, [MOT3+], acquired a variety of multicellular growth forms known to require FLO11 expression. This was a clear indication that prion formation was causing the differentiation of the cells and their subsequent cooperation. But what about the stress aspect of the hypothesis?

By testing yeast cells against a variety of stressors, the scientists discovered that exposure to a concentration of ethanol akin to that occurring naturally during fermentation increased [MOT3+] formation by a factor of 10.They also found that as the cells exposed to ethanol shifted their metabolism to burn surrounding oxygen through respiration, the prions reverted to their non-prion conformation, [mot3-], and the yeast returned to the unicellular state. In essence, prion formation drove a shift to multicellularity, helping the yeast to ride out the ethanol storm.

"What we have in the end is two sequential environmental changes that are turning on a heritable epigenetic element and then turning it off," says Halfmann. "And between those two changes, the prion is causing the cells to acquire a multicellular growth form that we think is actually important for their survival."

Lindquist, who is also a Howard Hughes Medical Institute investigator, has long argued that prions have played a vital role in yeast evolution and has amassed a body of strong supporting evidence.

"We see them as part of a bet-hedging strategy that allows the yeast to alter their biological properties quickly when their environments turn unfavorable," Lindquist says. She also theorizes that prions may play such roles beyond yeast, and her lab intends to take similar approaches in the hunt for prions and prion-like mechanisms that are potentially beneficial in other organisms.

For Lindquist lab postdoctoral scientist Alex Lancaster, who is also an author of the new Cell paper, these latest findings hint at a potentially novel approach to understanding basic mechanisms underlying the complexities of human diseases, including cancer, whose hallmarks include protein misfolding, epigenetic alterations, metabolic aberrations, and myriad changes in cell state, type, and function. Lancaster likens the opportunity to that of opening a black box.

"It's exciting to think that this could become another tool in the toolbox in the study of multicellularity," Lancaster says. "We know that some tumors are a heterogeneous population of cells and we know that tumor cells can evolve within in their environments to help ensure their own survival. This system could help us further understand the role of epigenetic inheritance within tumors and how it might be influencing cell-cell interactions and even affecting the effectiveness of drug therapies."

###

Whitehead Institute for Biomedical Research: http://www.wi.mit.edu/index.html

Thanks to Whitehead Institute for Biomedical Research for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127516/Protective_prion_keeps_yeast_cells_from_going_it_alone

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Mashreq upgrades Small Business Loan with higher loan amount ...

Mashreq Business Banking offers this product with some exclusive benefits, which will further assist individuals to realize their business goals.

These loans are now available to companies with only 2 years of business vintage. This will help the small businesses meet their funding needs for business expansion. In addition the loan size can now go up to Dhs1.5m.

Small Business Loan from Mashreq is a collateral free multipurpose amortizing loan offering, with a host of benefits like free business value current account with no minimum balance requirement, free debit card and a free cheque book. Customers can avail Sharia'h Compliant solutions as well.

Rohit Garg, Head of Business Banking at Mashreq commented, "The SME market is witnessing a strong comeback and there is a positive momentum in the recent period. With the enhancement of the Small Business Loan offering, we are continuing our support towards the growth and sustainability of this segment. Our range of products and services reflect on Mashreq's commitment as proud partners of SME's. Our wide branch network certainly assists to accommodate customer requirements wherever they maybe."

The bank is also running a special offer for this product wherein customers will receive a free laptop with Windows 8, Microsoft office and antivirus software.

Business Banking from Mashreq offers a comprehensive range of products and solutions, which cater to the needs of SMEs at every stage of their Business life cycle. Other financing solutions include Trade and Working Capital solutions and the unique Merchant Over Draft Facilities which is exclusively offered based on the company's Point of Sale throughput.

Furthermore, the Bank also offers Business Accounts & Debit Cards, Foreign Exchange and remittance solutions and Business Insurance for the benefit of the SMEs.

Source: http://www.ameinfo.com/mashreq-upgrades-business-loan-loan-amount-335435

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Doug Gottlieb Cracks Awkward "White Man" Joke on CBS Pregame Show

Source: http://www.thehollywoodgossip.com/2013/03/doug-gottlieb-cracks-awkward-white-man-joke-on-cbs-pregame-show/

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Construction marketing through the long sales cycle | Gorilla 76

Web marketing resources and ideas for B2B companies

by Joe Sullivan

When a business hires a contractor, it?s not exactly like heading to the mall for a new pair of shoes. It?s a really big decision with a long sales cycle. And it?s a decision that often involves a lot of people, a lot of politics, a lot of money and therefore a lot of research.

New prospects come from many places ? referrals, lists, trade show introductions, advertisements, Google searches. However they find you, they still need to qualify you. What?s your reputation? What similar work have you completed for other clients? Can you meet their budget requirements? So while a buyer of construction services researches, evaluates their options and narrows down their decision to a handful of potential contractors, what can you be doing to influence their buying decision?

You can qualify your business and educate your buyer with resources designed just for them. And there is no better avenue for this content marketing approach than your company?s website.

Help your prospect research

Whether they find you on your own or through referral, prospective customers in the research stage need to qualify your business. They want to learn about you and believe that you?re potentially a good fit before they go any further. Descriptive website pages about your services as well as articles (blog posts) that demonstrate your philosophy and expertise are the perfect formula to capture their interest for the first time.

Help your prospect evaluate

After you?ve earned their attention and have established some baseline trust in your ability to serve them, they?ll require more in-depth information to further qualify you. Case studies are a great solution ? and by case studies, I don?t mean project profiles with a picture, square footage and job location. I mean descriptive overviews of your client?s problem, how you solved it and what results you delivered. Did you come in under budget? Ahead of time? What hurdles did you overcome along the way? And what did your client have to say about working with you? This is what evaluators want to learn. White papers and more technical, detailed blog posts will also help move you onto their short list.

Help your prospect make a buying decision

Sometimes it comes down to low bid. We get it. But our work with construction industry businesses (particularly those targeting the private sector) has shown us that something needs to set you apart. What can you offer that helps shift a buyer?s focus to you? If your business provides free consultations, site visits, audits or other conversation-starting services, it?s a no-brainer to represent these entry-point offers on your website. Detail them on pages equipped with lead-capure opportunities and ask your prospect to inquire.

Ideas for construction marketing content

The infographic below illustrates content ideas to offer your prospect along their journey to a buying decision.

Content marketing for construction industry



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Source: http://www.gorilla76.com/blog/construction-marketing-through-the-long-sales-cycle,4053/

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Friday, March 29, 2013

frolicEARTH :: Your Green-Minded Action Sports and Outdoor ...

It?s impossible to talk about all of the World?s fantastic trails but it is worth adding each and every one of these to your bucket list. If you never walk any other trails you?ll die happy having walked these. The list is suitable for hardened hikers and newbies alike, having easier alternative routes when the going gets tough. Hiking gives unparalleled access to the most natural and beautiful places on Earth and rewards hikers with a fantastic sense of achievement at the end too. Here are 5 of the best trails on Earth spread over 4 continents:

The Inca Trail, Peru. This is one of the most famous but also one of the most spectacular trails on Earth, ending with the preverbal cherry on top; the ancient city of Machu Picchu, where you?ll get to explore the ruins of a civilization now lost. History and archaeology fans will enjoy the sensation of stepping back in time to a place absolutely removed from modern culture to marvel at the feats of engineering that the Incas achieved.

Image source: Emmanuel Dyan

The trail itself is demanding and you must stop along the way as you climb higher to give your body time to acclimatise. You need a pass to walk this trail and the number of people allowed through each day is restricted so be sure to book and show up on the day. It takes around 4 days to reach Machu Picchu from Cusco, the route taking you through forests, valleys and up 4000 metres into the sky.

When to go: April to October.

The Narrows, Zion NP, Utah, USA. Utah is an amazing spot for hikers and fans of outdoor activities in general, holding a total of 5 national parks. The landscape is dotted with incredible canyons that provide ample opportunity for wading or swimming along the way. The Narrows trails sets you right inside the canyon of the Virgin River, walking in the water if you like. You can dip in and out of this trail, taking your time or covering it in a day. For river hiking it?s important to have the right gear which should include special river hiking shoes. It is worth the extra cost of getting special gear and once you?ve experienced this sort of trail you?ll want to come back or find more like it, making plenty of use of your new shoes. Zion National Park has 12 camping sites so it?s easy to find somewhere to pitch up at night.

Zion National Park, UtahImage source: garrellmillhouse

When to go: You can hike in Utah year round but in general spring and autumn are the prime hiking seasons due to the more temperate weather at these times of year. However you might like to visit The Narrows during the summer, avoiding the usual crowds in the region as you?ll have plenty of shade and cool water as you hike inside the canyon of the Virgin River. The water level will also be lower and you?ll avoid the risk of flash flooding.

Drakensberg Mountains, South Africa. This mountain range stretches 1000km South West to North East along the Eastern side of South Africa and into Lesotho. Treks can be arranged from Durban, taking you from South to North, and tailored to you; hiking in the Drakensberg Mountains for between 3 and 7 days depending on your fitness levels.

What?s special about hiking in the Drakensberg Mountains is the chance to sleep in one of the many caves in the region. These ?caves? are formed of overhangs in the sandstone hillsides and make fantastic overnight rest spots. They must have served as shelter to the local people too because here in the mountains is the largest collection of bushmen art in the world, comprising of 20,000 different in cave paintings.

Drakensburg Mountains, South AfricaImage source: Wild About Travel

The second highest waterfall in the world is here too, Tugela Falls. For the best views of the falls take a trail up Mount-Aux-Sources and continue climbing to the Amphitheatre escarpment. The landscape here is magnificent; combining high rocky outcrops with luscious lowland grass and forest.

When to go: Hikes can be arranged all year round so it depends on your tastes, experiences and expectations when you make your visit. The Tugela Falls will be most impressive after rains so the summer months (October to March) would be an ideal time for a route that takes in the falls.

Mountains of the Moon, Uganda. This is a challenging 9 day hike taking you through jungle and bog, up mountains over 4000 metres high, passing by glaciers and descending again into bamboo forests. This is a unique trail that promises great walking and climbing routes with an animal-spotting safari too. If you?re lucky you may walk a glacier and see an elephant on the same day. Many guided tours will include a gorilla watching section during your hike.

Mountains of the Moon, UgandaImage source: clemgirardot

The Mountains of the Moon which are part of Uganda?s Rwenzori Mountains is the highest mountain range in Africa. Parts of the trail look down into the Congo basin, a thick jungle that is one of the world?s most important wildernesses and is home to several types of gorilla, elephant and chimp.

When to go: December to March.

Bay of Fires, Tasmania, Australia Tasmania, off the coast of Australia, offers something totally different to the above; a short seaside trail of only 16 miles. If you?ve never thought of hiking along white sand beaches looking out on the crystal clear Tasman Sea then start thinking about it. This is different to mountainous country walks or desert canyon trails because although you?ll find paradise on all of these trails nothing looks quite as heavenly as these beautiful beaches.

This is a fairly easy walk following the flat coastline around but encompassing a couple of headlands to keep your interest up. You?ll need to take a guided tour due to the lack of fresh water and scarcity of permanent overnight camps along the route. It?s also useful to have someone with lots of experience of the area with you as there are many snakes on Tasmania, all of which have a pretty nasty bite.

Bay of Fires, TasmaniaImage source: ekieraM

This is perfect for a mini break from the luxuries of a Tasmanian holiday. The facilities along the way are basic e.g. hand pumped water for showering but this adds to the feeling of getting away to a deserted island, if just for 2 or 3 days.

kirstysampson

Kirsty Sampson is an aspiring blogger from Manchester (UK), blogging about a wide variety of topics. Follow her on Twitter @kirstysampson1

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Source: http://www.frolicearth.com/2013/03/hiking-holidays-5-of-the-best-trails-on-earth/

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How herpesvirus invades nervous system

Mar. 27, 2013 ? Northwestern Medicine scientists have identified a component of the herpesvirus that "hijacks" machinery inside human cells, allowing the virus to rapidly and successfully invade the nervous system upon initial exposure.

Led by Gregory Smith, associate professor in immunology and microbiology at Northwestern University Feinberg School of Medicine, researchers found that viral protein 1-2, or VP1/2, allows the herpesvirus to interact with cellular motors, known as dynein. Once the protein has overtaken this motor, the virus can speed along intercellular highways, or microtubules, to move unobstructed from the tips of nerves in skin to the nuclei of neurons within the nervous system.

This is the first time researchers have shown a viral protein directly engaging and subverting the cellular motor; most other viruses passively hitch a ride into the nervous system.

"This protein not only grabs the wheel, it steps on the gas," says Smith. "Overtaking the cellular motor to invade the nervous system is a complicated accomplishment that most viruses are incapable of achieving. Yet the herpesvirus uses one protein, no others required, to transport its genetic information over long distances without stopping."

Herpesvirus is widespread in humans and affects more than 90 percent of adults in the United States. It is associated with several types of recurring diseases, including cold sores, genital herpes, chicken pox, and shingles. The virus can live dormant in humans for a lifetime, and most infected people do not know they are disease carriers. The virus can occasionally turn deadly, resulting in encephalitis in some.

Until now, scientists knew that herpesviruses travel quickly to reach neurons located deep inside the body, but the mechanism by which they advance remained a mystery.

Smith's team conducted a variety of experiments with VP1/2 to demonstrate its important role in transporting the virus, including artificial activation and genetic mutation of the protein. The team studied the herpesvirus in animals, and also in human and animal cells in culture under high-resolution microscopy. In one experiment, scientists mutated the virus with a slower form of the protein dyed red, and raced it against a healthy virus dyed green. They observed that the healthy virus outran the mutated version down nerves to the neuron body to insert DNA and establish infection.

"Remarkably, this viral protein can be artificially activated, and in these conditions it zips around within cells in the absence of any virus. It is striking to watch," Smith says.

He says that understanding how the viruses move within people, especially from the skin to the nervous system, can help better prevent the virus from spreading.

Additionally, Smith says, "By learning how the virus infects our nervous system, we can mimic this process to treat unrelated neurologic diseases. Even now, laboratories are working on how to use herpesviruses to deliver genes into the nervous system and kill cancer cells."

Smith's team will next work to better understand how the protein functions. He notes that many researchers use viruses to learn how neurons are connected to the brain.

"Some of our mutants will advance brain mapping studies by resolving these connections more clearly than was previously possible," he says.

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The above story is reprinted from materials provided by Northwestern University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Sofia?V. Zaichick, Kevin?P. Bohannon, Ami Hughes, Patricia?J. Sollars, Gary?E. Pickard, Gregory?A. Smith. The Herpesvirus VP1/2 Protein Is an Effector of Dynein-Mediated Capsid Transport and Neuroinvasion. Cell Host & Microbe, 2013; 13 (2): 193 DOI: 10.1016/j.chom.2013.01.009

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/DpfJns9Ndl0/130328091754.htm

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Are 3-D printers coming to American homes?

On the show

57 minutes ago

3-D printing is a quickly developing tool that allows young innovators to create products that are usually the exclusive province of high-cost manufacturers. Glenn Derene, senior technology editor at Popular Mechanics, demonstrates the basics of 3-D printing to Matt Lauer and explains the potential benefits of having one at home.


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Amazon to buy Goodreads for undisclosed sum

NEW YORK (AP) ? Amazon, the world's biggest online retailer that got its start in bookselling, is agreeing to buy book recommendations site Goodreads.

Financial terms of the deal were not disclosed. Amazon said Thursday that it "shares a passion for reinventing reading," with Goodreads.

In addition to recommending books to read based on what other books people have liked, Goodreads also serves as a social network for bookworms. It has 16 million members.

The deal is expected to close in the second quarter. Seattle-based Amazon.com Inc. says Goodreads headquarters will remain in San Francisco.

Source: http://news.yahoo.com/amazon-buy-goodreads-undisclosed-sum-211250545.html

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Thursday, March 28, 2013

Dusting for prints from a fossil fish to understand evolutionary change

Mar. 27, 2013 ? In 370 million-year-old red sandstone deposits in a highway roadcut, scientists have discovered a new species of armored fish in north central Pennsylvania.

Fossils of armored fishes like this one, a phyllolepid placoderm, are known for the distinctive ornamentation of ridges on their exterior plates. As with many such fossils, scientists often find the remains of these species as impressions in stone, not as three-dimensional versions of their skeletons. Therefore, in the process of studying and describing this fish's anatomy, scientists took advantage of a technique that may look a lot like it was stolen from crime scene investigators.

Dr. Ted Daeschler has shown the fossil and made a rubber cast by pouring latex into its natural impression in the rock. Once the latex hardened, Daeschler peeled it out and dusted its surface with a fine powder to better show the edges of the bony plates and the shapes of fine ridges on the fish's bony armor -- a lot like dusting for fingerprints to show minute ridges left on a surface. With this clearer view, Daeschler and colleagues were better able to prepare a detailed scientific description of the new species.

This placoderm, named Phyllolepis thomsoni, is one of two new Devonian fish species described by Daeschler in the Bicentennial issue of the Proceedings of the Academy of Natural Sciences of Philadelphia, with different co-authors. The other new species is a lobe-finned fish discovered in northern Canada.

Both the Pennsylvania placoderm and the Canadian lobe-finned fish species are from the late Devonian period, at a time long before dinosaurs walked the Earth -- but, geologically speaking, not long before the very first species began to walk on land. Daeschler studies Devonian species in particular to help describe the evolutionary setting that gave rise to the first vertebrate species with limbs. He has dug for Devonian species in Pennsylvania since 1993, and in northern Canada since 1999.

Daeschler, a vice president and associate curator at the Academy of Natural Sciences of Drexel University, and an associate professor in Drexel's College of Arts and Sciences, and co-author Dr. John A. Long, a leading authority on placoderms from Flinders University in Australia, named the species in honor of Dr. Keith S. Thomson.

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The above story is reprinted from materials provided by Drexel University. The original article was written by Rachel Ewing.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/DHOvUao5kcU/130327104154.htm

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How To Get Down To Renting A Campervan

Campervanning in has already been an integral part of the people that are looking to go for a vacation. In fact is now one of the most ideal means for anyone looking for a fun and safe adventure that give value for the money spent. Many travelers now favor the to renting and traveling in a campervan than opting for a regular automobile; even people have been doing so in the past.

The benefits of choosing to hire and travel with a camper van are varied according to lucky rentals, the New Zealand campervan rental firm. Some people it double the fun, some say it is cheaper that hotels or taking flights to different place. Some say it is more sociable etc.

But for this to happen, planning is the first process to ultimately ensure one get the most satisfying holiday. Some people actually do it a year in advance and have done it many times before in a campervan. Some people are planning their first ever campervan road trip. The others are also planning to buy an RV, but would not justify the price of buying one if the intention is by using it sporadically.

Well, anyone that is legally an adult can rent a campervan. In fact hiring a camper is simply comparable to hiring a normal car. We are talking about medium to large cars that carry the fundamental services of a home. Campervans may also be linked to trailers, vehicle trailers, motor home, and also 4WD with folding camper utilities.

As the popularity of campervans have grown there are now many types of campervans built to cater to different people but generally it is between two possibilities, the budget and the luxury. When it comes to size concerns, like renting a vehicle the size must be specific. The seatbelt capacity should not be exceeded by the number of people. It goes the same with campervans, but it is usually regarded to the capacity of the camper. You will find 5 sizes i.e. the 2 3, 4, 5 and last but not least the 6berth. The other size is the 2.5 berth. The 2.5berth campervan, means that it could rest 2 adults and 1 child. But generally the most common are 2, 4 and 6berth campervans.

The number preceding the term "berth" suggest the sleeping capacity of the automobile. Other things you will need to think about when selecting a campervan will be the facilities that it gives. You may desire a toilet, shower on your own trip, and you may not. Needless to say the vehicle with more features is more expensive compared to simple one. Generally, each camper has simple entertainment, cooking and sleeping facilities. And one way of picking right the van is to go for one that'll accommodate both your budget and needs.

About the Author:
You make reservations early enough at lucky rentals, you will be able to get a fully geared up cheap campervan hire. All campervans and sleepervans are fully equipped with duvet,towels, cutlery, crockery, pots and pans, toaster, kettle, gas kettle and much more. You can even pick up or drop your campervan off any time of the day or night.We guarantee the lowest cost New zealand campervan rental.

Source: http://www.articlesnatch.com/Article/How-To-Get--Down-To-Renting-A-Campervan/4505431

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Engineers enable 'bulk' silicon to emit visible light for the first time

Mar. 27, 2013 ? Electronic computing speeds are brushing up against limits imposed by the laws of physics. Photonic computing, where photons replace comparatively slow electrons in representing information, could surpass those limitations, but the components of such computers require semiconductors that can emit light.

Now, research from the University of Pennsylvania has enabled "bulk" silicon to emit broad-spectrum, visible light for the first time, opening the possibility of using the element in devices that have both electronic and photonic components.

The research was conducted by associate professor Ritesh Agarwal, postdoctoral fellow Chang-Hee Cho and graduate students Carlos O. Aspetti and Joohee Park, all of the Department of Materials Science and Engineering in Penn's School of Engineering and Applied Science.

Their work was published in Nature Photonics.

Certain semiconductors, when imparted with energy, in turn emit light; they directly produce photons, instead of producing heat. This phenomenon is commonplace and used in light-emitting diodes, or LEDs, which are ubiquitous in traffic signals, new types of light bulbs, computer displays and other electronic and optoelectronic devices. Getting the desired photonic properties often means finding the right semiconducting material. Agarwal's group produced the first ever all-optical switch out of cadmium sulfide nanowires, for example.

Semiconducting materials -- especially silicon -- form the backbone of modern electronics and computing, but, unfortunately, silicon is an especially poor emitter of light. It belongs to a group of semiconducting materials, which turns added energy into heat. This makes integrating electronic and photonic circuits a challenge; materials with desirable photonic properties, such as cadmium sulfide, tend to have poor electrical properties and vice versa and are not compatible with silicon-based electronic devices.

"The problem is that electronic devices are made of silicon and photonic devices are typically not," Agarwal said. "Silicon doesn't emit light and the materials that do aren't necessarily the best materials for making electronic devices."

With silicon entrenched as the material of choice for the electronics industry, augmenting its optical properties so it could be integrated into photonic circuitry would make consumer-level applications of the technology more feasible.

"People have tried to solve this problem by doping silicon with other materials, but the light emission is then in the very long wavelength range, so it's not visible and not very efficient and can degrade its electronic properties," Agarwal said. "Another approach is to make silicon devices that are very small, five nanometers in diameter or less. At that size you have quantum confinement effects, which allows the device to emit light, but making electrical connections at that scale isn't currently feasible, and the electrical conductivity would be very low."

To get elemental, "bulk" silicon to emit light, Agarwal's team drew upon previous research they had conducted on plasmonic cavities. In that earlier work, the researchers wrapped a cadmium sulfide nanowire first in a layer of silicon dioxide, essentially glass, and then in a layer of silver. The silver coating supports what are known as surface plasmons, waves that are a combination of oscillating metal electrons and of light. These surface plasmons are highly confined to the surface where the silicon dioxide and silver layers meet. For certain nanowire sizes, the silver coating creates pockets of resonance and hence highly confined electromagnetic fields -- in other words, light -- within the nanostructure.

Normally, after excitation the semiconductor must first "cool down," releasing energy as heat, before "jumping" back to the ground state and finally releasing the remaining energy as light. The Penn team's semiconductor nanowires coupled with plasmonic nanocavities, however, can jump directly from a high-energy excited state to the ground state, all but eliminating the heat-releasing cool-down period. This ultra-fast emission time opens the possibility of producing light from semiconductors such as silicon that might otherwise only produce heat.

"If we can make the carriers recombine immediately," Agarwal said, "then we can produce light in silicon."

In their latest work, the group wrapped pure silicon nanowires in a similar fashion, first with a coating of glass and then one of silver. In this case, however, the silver did not wrap completely around the wire as the researchers first mounted the glass-coated silicon on a sperate pane of glass. Tucking under the curve of the wire but unable to go between it and the glass substrate, the silver coating took on the shape of the greek letter omega -- ? -- while still acting as a plasmonic cavity.

Critically, the transparent bottom of the omega allowed the researchers to impart energy to the semiconductor with a laser and then examine the light silicon emitted.

Even though the silicon nanowire is excited at a single energy level, which corresponds to the wavelength of the blue laser, it produces white light that spans the visible spectrum. This translates into a broad bandwidth for possible operation in a photonic or optoelectronic device. In the future, it should also be possible to excite these silicon nanowires electrically.

"If you can make the silicon emit light itself, you don't have to have an external light source on the chip," Agarwal said. "We could excite the silicon electrically and get the same effect, and we can make it work with wires from 20 to 100 nanometers in diameter, so it's very compatible in terms of length scale with current electronics."

The research was supported by the U.S. Army Research Office and the National Institutes of Health.

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Journal Reference:

  1. Chang-Hee Cho, Carlos O. Aspetti, Joohee Park, Ritesh Agarwal. Silicon coupled with plasmon nanocavities generates bright visible hot luminescence. Nature Photonics, 2013; 7 (4): 285 DOI: 10.1038/nphoton.2013.25

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/computers_math/information_technology/~3/U1h28iUkbn4/130327133517.htm

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Dad denies using daughter in child-porn extortion plot after professor's suicide

FBI agents say a blackmail scheme concocted by another man who used photos of an underage girl in a catfish scam may have caused a Texas A&M professor to commit suicide. KPRC's Irika Sargent reports.

By Juan A. Lozano, The Associated Press

HOUSTON -- A Louisiana man denied on Tuesday that he used his daughter to lure a college professor into a sexually explicit online relationship and then blackmailed him.

The professor, James Arnt Aune, of Texas A&M University, jumped to his death from the roof of a campus parking garage in January after paying part of an alleged demand for $5,000, sending a text to the man saying "Killing myself now. And u will be prosecuted for black mail."

Authorities allege that Aune, 59, was one of many victims of the same scam by the man. The Associated Press isn't naming him to protect the identity of his daughter.

Aune, who headed the school's Department of Communication, battled depression in recent years. He struggled with the administrative duties of being a department head, and he was badly shaken by his 2007 battle with prostate cancer, his widow said. "He never really came all the way back," Miriam Aune said of his surviving cancer.

He began drinking heavily, and in December he started a sexually explicit online relationship with what he thought was an underage girl, according to prosecutors. He was soon contacted by a man purporting to be her outraged father, who threatened to expose Aune unless he paid him $5,000.

Aune paid the man $1,500, but he didn't know if he could come up with the rest, authorities say.

The alleged blackmailer pleaded not guilty Tuesday in a Houston federal courtroom to an extortion charge.

The 37-year-old Metairie, La., resident was ordered to remain in jail without bail, and his trial is scheduled for May 28. If convicted, he faces up to two years in jail.

'A weak moment'
In the criminal complaint, prosecutors contend that the man's daughter told authorities in Louisiana in 2011 that her father took naked photos and videos of her and used them "to scam men" through MocoSpace, a social networking website mainly for mobile devices. On the site, "she would meet men, get their phone numbers and send them pictures and videos then (her father) would call them and say how she was his daughter and how she would need counseling and they had to pay for it."

At the time of that 2011 interview, her father was facing two counts of oral sexual battery and two counts of aggravated incest. The charges were dropped in February 2012 due to a lack of corroborating evidence, said Rachael Domiano, a spokeswoman for the 21st Judicial District Attorney's Office in Louisiana.

It wasn't clear from the criminal complaint if prosecutors believe the defendant's daughter actually interacted with Aune, or if her image was used to allegedly dupe him.

Miriam Aune, 56, told The Associated Press that investigators told her that the defendant communicated with her husband and other men, pretending to be his daughter.

She said her husband told her he began the online chats sometime in December and the defendant then asked for money.

According to court records, undated texts show Aune scrambling to put money on prepaid credit cards and asking for his forgiveness, saying "I am very sorry. It was a weak moment."

A week before his suicide, James Aune confessed to his wife. Miriam Aune said her husband never told her why he did it.

"I was just telling him there was nothing that we couldn't get through. We have two autistic children we have raised to adulthood. We've been through rough stuff. I thought we could get through this," Miriam Aune said.

According to a criminal complaint, the defendant continued bombarding Aune with profanity laced emails, texts and voicemails, including a Jan. 7 email in which he warned Aune that he had until noon the next day to pay or else "the police, your place of employment, students, ALL OVER THE INTERNET ...ALL OF THEM will be able to see your conversations, texts, pictures you sent ...."

On Jan. 8 at 9:21 a.m., the defendant texted, "3 more hours. If i don't hear from you the calls start," according the criminal complaint by FBI agent Nikki Allen. Just over an hour later, Aune replied with the text to say he was taking his own life.

Miriam Aune doesn't excuse her husband's actions. She said it was his decision to go online and begin the conversations.

"It just shows you anybody can slip off the path. I know a lot of people are very surprised by this. He was very human with flaws, just like all of us," she said.?

? 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Wednesday, March 27, 2013

Timberlake's '20/20' album sells 968K in 1st week

FILE - This Feb. 20, 2013 file photo shows Justin Timberlake during the BRIT Awards 2013 in London. Nielsen SoundScan announced Tuesday, March 26, 2013, that the singer?s third album, ?The 20/20 Experience,? has moved 968,000 units. It?s the 19th album in Nielsen?s 12-year history that has sold more than 900,000 albums in a single week. (Photo by Joel Ryan/Invision/AP, file)

FILE - This Feb. 20, 2013 file photo shows Justin Timberlake during the BRIT Awards 2013 in London. Nielsen SoundScan announced Tuesday, March 26, 2013, that the singer?s third album, ?The 20/20 Experience,? has moved 968,000 units. It?s the 19th album in Nielsen?s 12-year history that has sold more than 900,000 albums in a single week. (Photo by Joel Ryan/Invision/AP, file)

(AP) ? Justin Timberlake's comeback album has sold nearly 1 million units its first week out.

Nielsen SoundScan announced Tuesday that the singer's third album, "The 20/20 Experience," has moved 968,000 units. It's the 19th album in Nielsen's 12-year history that has sold more than 900,000 albums in a single week.

"20/20" is Timberlake's third album and the follow-up to his multiplatinum, Grammy-winning 2006 album, "FutureSex/LoveSound." The new CD features the pop hit "Suit & Tie."

"The numbers are pleasantly surprising," said Tom Corson, the president and chief operating officer of RCA Records, which released Timberlake's album.

The label had projected that "20/20" would sell 500,000 to 600,000 units, Corson said.

Timberlake, 31, was strategic about promoting his comeback effort: He performed at the Grammy Awards, hosted and hit the stage at "Saturday Night Live" and spent an entire week on "Late Night with Jimmy Fallon." The singer also partnered with Target for the album's deluxe edition and "20/20" streamed on iTunes a week before it was released.

Timberlake came up with the idea of a weeklong stint himself, Fallon said.

"I think he mentioned it to me like a year ago that he's working on something and wanted to do a week on our show," Fallon said Tuesday.

"20/20" is an unconventional album that features a mesh of R&B, soul, pop and futuristic sounds. The 10 tracks average seven minutes each.

Corson believes Timberlake's key to promoting the album was "less is more."

"While it felt like he was everywhere, he didn't do a lot of things because he didn't have to. But he did big things," he said.

Fallon even joked that other celebrities are trying to follow in Timberlake's footsteps with a weeklong stay on his show.

"We're getting a lot of phone calls now to do themed-weeks for people," said Fallon, who added that the show's writers and producers developed a load of material for "Timberweek."

"We have enough for another month," he said. "We could have 'Timbermonth.' Trust me, NBC is already pitching it to me."

Of the 19 albums to sell more than 900,000 in a single week, Timberlake holds three slots. His albums with 'N Sync, 2000's "No Strings Attached" and 2001's "Celebrity," sold 2.4 million and 1.9 million in their first week, respectively. Backstreet Boys, Lil Wayne and Taylor Swift have two albums each that have hit that level.

The excitement over the new album has also boosted sales of Timberlake's other solo albums, Nielsen Co. said. Last year, "FutureSex/LoveSound" and 2002's "Justified" sold 39,000 and 21,000 copies each, but this year they've already sold 29,000 and 17,000, respectively.

"As the marketing sort of picks up for the new record and the single goes to radio ... you definitely start to see interest," said David Bakula, Nielsen's senior vice president of client development and analytics for entertainment.

Bakula said 'N Sync sales are up, too.

Fallon said Timberlake worked tirelessly ahead of the five shows and he's proud of his friend's success.

"Justin was here till 11 o'clock most nights choreographing dance moves so he nailed it the next night," he said. "And he was sick at the time."

Corson said this week's success could change the expectation of Timberlake's follow-up to "20/20," which will likely be released later this year.

"It sure should," he said with a laugh. "Part two is now even more anticipated."

Timberlake could even show up for a stint on Fallon again.

"We are already talking about it," Fallon said.

___

Online:

http://twentytwenty.justintimberlake.com/

http://http://www.latenightwithjimmyfallon.com/

___

Follow Mesfin Fekadu at http://twitter.com/MusicMesfin

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-03-26-Music-Justin%20Timberlake/id-6af594b0cc9a4fc59a3f4f56c6550a86

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Maybe Isolation, Not Loneliness, Shortens Life

NPR:

Loneliness hurts, but social isolation can kill you. That's the conclusion of a study of more than 6,500 people in the U.K.

The study, by a team at University College London, comes after decades of research showing that both loneliness and infrequent contact with friends and family can, independently, shorten a person's life. The scientists expected to find that the combination of these two risk factors would be especially dangerous.

Read the whole story at NPR

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Source: http://www.huffingtonpost.com/2013/03/26/maybe-isolation-not-lonel_n_2956840.html

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Green Car Congress: Lux: consumer electronics, not automotive, will ...

Lux: consumer electronics, not automotive, will drive next-gen battery development; solid-state over Li-S and Li-air

While much of the motivation for next-generation batteries comes from transportation, Lux Research?s analysis concludes that the automotive market will be the last to adopt next-generation batteries due to the extreme cost sensitivity of automakers, stringent safety and lifetime requirements, and long, cautious adoption cycles. Hence, makers of next-generation batteries will have to look to other markets first.

Designers of consumer electronics?the largest current Li-ion application?will move the next generation battery market more meaningfully as they continue to push towards devices with smaller footprints, according to Lux.

Analyzing the consumer electronics space, solid-state batteries will provide real completion to Li-ion in the consumer electronics market, offering tremendous technical value for a segment that prizes volumetric efficiency and low costs, according to the research firm. By 2020, solid-state will draw close to Li-ion as current complex manufacturing processes that are a challenge today are solved, costs fall and energy densities rise.

From this foundation, solid state will surge past Li-ion in technical value by 2030. Li-S will also make strong progress, but won?t quite match the well-rounded value propositions of solid-state and advancing Li-ion, finding only niche consumer electronics applications that prize excellent specific energy above all else. Li-air is a non-factor in this sector, hampered by its volumetric inefficiency and its need for peripherals, according to Lux.

Source: http://www.greencarcongress.com/2013/03/luc-20130325.html

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Tuesday, March 26, 2013

Botonists find novel way plants pass traits to next generation: Inheritance behavior in corn breaks accepted rules of genetics

Mar. 26, 2013 ? New research explains how certain traits can pass down from one generation to the next -- at least in plants -- without following the accepted rules of genetics.

Scientists have shown that an enzyme in corn responsible for reading information from DNA can prompt unexpected changes in gene activity -- an example of epigenetics.

Epigenetics refers to modifications in the genome that don't directly affect DNA sequences. Though some evidence has suggested that epigenetic changes can bypass DNA's influence to carry on from one generation to the next, this is the first study to show that this epigenetic heritability can be subject to selective breeding.

Researchers bred 10 generations of corn and found that one particular gene's activity persisted from one generation to the next whether the enzyme was functioning or not -- meaning typical genetic behavior was not required for the gene's trait to come through.

And that, the scientists determined, was because the enzyme targets a tiny piece of DNA -- previously thought of as "junk DNA" -- that had jumped from one area of the genome to another, giving that little fragment power to unexpectedly turn on the gene.

The gene in question affects pigmentation in the corn plant. As a result of these experiments, the researchers were able to change yellow kernel corn to a blue kernel variety by compromising the activity of the enzyme in each male parent.

"This is the first example where somebody has been able to take an epigenetic source of variation and, through selective breeding, move it from an inactive state to an active state," said Jay Hollick, associate professor of molecular genetics at The Ohio State University and lead author of the study. "The gene changes its expression in an epigenetic fashion and it doesn't follow standard inheritance behaviors. Those two factors alone have pretty profound implications not only for breeding but also for evolution."

The study appears online in the journal The Plant Cell.

Plant breeders tend to expect to generate desired traits according to what is known as Mendelian principles of inheritance: Offspring receive one copy of genes from each parental plant, and the characteristics of the alleles, or alternative forms of genes, help predict which traits will show up in the next plant generation.

However, epigenetic variations that change the predictability of gene behavior have complicated those expectations.

"The breeding community searches for novel traits that will have commercial interest and they really don't care what the basis is as long as they can capture it and breed it. Epigenetic heritability throws a kink in the expectations, but our findings also provide an opportunity -- if they recognize the variation they're looking for is the result of epigenetics, they could use that to their advantage," said Hollick, also an investigator in Ohio State's centers for RNA Biology and Applied Plant Sciences.

"Just by knowing that this allele behaves in this epigenetic fashion, I can breed plants that either have full coloration or no coloration or anything in between, because I am manipulating epigenetic variation and not genetic variation. And color, of course, is only one trait that could be affected."

With a longtime specialization in the molecular basis for unexpected gene activity in plants, Hollick had zeroed in on an enzyme called RNA polymerase IV (Pol IV). Multiple types of RNA polymerases are responsible for setting gene expression in motion in all cells, and Pol IV is an enigmatic RNA polymerase that is known in plants to produce small RNA molecules.

Pol IV has puzzled scientists because despite its strong conservation in all plants, it appears to have no discernible impact on the development of Arabidopsis, a common model organism in plant biology. For example, when it is deleted from these plants, they show no signs of distress.

In corn, however, Hollick's lab had discovered previously that the absence of Pol IV creates clear problems in the plants, such as growing seeds in the tassel.

Hollick and colleagues observed that plants deficient in Pol IV also showed pigmentation in kernels of ears expected not to make any color at all -- meaning they were expected to be yellow.

"Since we knew the misplaced tassel-seed trait was due to misexpression of a gene, we hypothesized that this pigment trait might be due to a pigment regulator being expressed in a tissue where it normally is never expressed. Molecular analysis showed that that was in fact the case," Hollick said.

The researchers selected dark kernels and light kernels from multiple generations of plants and crossed the plants derived form these different kernel classes to create additional new generations of corn.

"We found that the ears developed from those plants had even more darkly colored kernels and fewer lightly colored kernels. We could segregate the extreme types and cross them together and get this continued intensification of the pigmentation over many generations," he said. "We generated more progeny that had increasing amounts of pigment. This is taking a gene that is genetically null, that doesn't have any function in this part of the plant, and turning it from a complete null to a completely dominant form that produces full coloration.

"Essentially we were breeding a novel trait, but not by selecting for any particular gene. We were just continually altering the epigenetic status of one of the two parental genomes every time."

This led the scientists to question why the affected alleles of the pigmentation gene would behave in this way. An investigation of the affected alleles revealed the nearby presence of a transposon, or transposable element: a tiny piece of DNA that has leapt from one area of the genome to another.

Because the sequence of some small RNA fragments that come from Pol IV's activity are identical to the sequence of these transposons, the finding made sense to the scientists.

"Now that we know that Pol IV is involved in regulating transposons, it's not surprising that genes that are near transposons are now regulated by Pol IV," Hollick said.

This work was supported by the National Research Initiative of the USDA Cooperative State Research, Education and Extension Service and the National Science Foundation.

Hollick conducted this work at the University of California, Berkeley, before he joined Ohio State's faculty. Co-authors are former Berkeley colleagues Karl Erhard Jr., Susan Parkinson, Stephen Gross, Joy-El Barbour and Jana Lim.

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The above story is reprinted from materials provided by Ohio State University.

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Journal Reference:

  1. K. F. Erhard, S. E. Parkinson, S. M. Gross, J.-E. R. Barbour, J. P. Lim, J. B. Hollick. Maize RNA Polymerase IV Defines trans-Generational Epigenetic Variation. The Plant Cell, 2013; DOI: 10.1105/tpc.112.107680

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/bzvdDxaq0K8/130326112003.htm

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